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Chỉ định và Liều dùng
Oral
Seasonal allergic rhinitis Adult: Each tab contains fexofenadine 60 mg and pseudoephedrine 120 mg: 1 tab bid. Each tab contains fexofenadine 180 mg and pseudoephedrine 240 mg: 1 tab once daily.
Child: ≥12 yr Same as adult dose. |
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Suy thận
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Chống chỉ định
Severe HTN or coronary artery disease, narrow-angle glaucoma, urinary retention. Patient receiving MAOIs or w/in 14 days of MAOI therapy withdrawal.
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Thận trọng
Patient w/ CV disease (e.g. HTN, ischaemic heart disease), DM, thyroid dysfunction, increased intraocular pressure, prostatic hypertrophy or urinary obstruction, seizure disorder. Renal impairment. Pregnancy and lactation.
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Tác dụng không mong muốn
Palpitations, abdominal pain, indigestion, nausea, headache, insomnia, agitation, upper resp infection.
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Chỉ số theo dõi
Monitor CNS effects (e.g. stimulation or depression).
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Tương tác
Increased plasma levels w/ ketoconazole or erythromycin. Increased CNS effect w/ other sympathomimetic amines. Increased ectopic pacemaker activity w/ digitalis. Decreased plasma levels w/ Al and Mg containing antacids. May reduce the effect of antihypertensive drugs which interfere w/ sympathetic activity (e.g. methyldopa, mecamylamine, reserpine).
Potentially Fatal: Enhanced hypertensive effect w/ MAOIs. |
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Tương tác với thức ăn
Reduced bioavailability and exposure w/ grapefruit, orange and apple juice.
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Tác dụng
Description:
Mechanism of Action: Fexofenadine is a selective peripheral H1-receptor antagonist thus, inhibits antigen-induced bronchospasm and histamine release. Pseudoephedrine exerts decongestant effect on the nasal mucosa. Pharmacokinetics: Absorption: Fexofenadine: Rapidly absorbed from the GI tract. Time to peak plasma concentration: 2-3 hr. Pseudoephedrine: Readily absorbed from the GI tract. Distribution: Fexofenadine: Plasma protein binding: Approx 60-70%. Pseudoephedrine: Enters breast milk (small amounts). Metabolism: Fexofenadine: Hepatically (approx 5% of the total dose). Pseudoephedrine: Hepatically (<1% of the total dose). Excretion: Fexofenadine: Via faeces (80%), urine (11%). Elimination half -life: Approx 14 hr. Pseudoephedrine: Via urine (55-75%, as unchanged drug). Elimination half-life: Approx 5-8 hr. |
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Đặc tính
 Source: National Center for Biotechnology Information. PubChem Database. Fexofenadine, CID=3348, https://pubchem.ncbi.nlm.nih.gov/compound/Fexofenadine (accessed on Jan. 20, 2020)  Source: National Center for Biotechnology Information. PubChem Compound Summary for CID 7028, Pseudoephedrine. https://pubchem.ncbi.nlm.nih.gov/compound/Pseudoephedrine. Accessed June 28, 2022. |
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Bảo quản
Store between 20-25°C.
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Phân loại MIMS
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Phân loại ATC
R01BA02 - pseudoephedrine ; Belongs to the class of systemic sympathomimetic preparations used as nasal decongestants.
R06AX26 - fexofenadine ; Belongs to the class of other antihistamines for systemic use. |
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Tài liệu tham khảo
Allegra-D 24 Hour Tablet, Film Coated (Sanofi-Aventis U.S. LLC). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 29/06/2015. Anon. Fexofenadine and Pseudoephedrine. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 29/06/2015. Buckingham R (ed). Fexofenadine Hydrochloride. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 29/06/2015. Buckingham R (ed). Pseudoephedrine. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 29/06/2015.
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